Citation
Gait Analysis in Aged Parkinsonian Mice

Material Information

Title:
Gait Analysis in Aged Parkinsonian Mice
Creator:
Becsey, Xavier
Publisher:
University of Florida
Publication Date:
Language:
English

Subjects

Subjects / Keywords:
Undergraduate Honors Thesis/Project

Notes

Abstract:
This study aimed to provide a deeper understanding of the motor impairments related to Parkinson's disease in the literature by analyzing the long-term gait performance of Parkinsonian mice possessing a unique a-syn misfolding and aggregation phenotype (M83+/-). The aim of this thesis was to conduct a comparative analysis of gait patterns between M83+/- mice and a control group at 12 and 52 weeks old. This research endeavor seeked to address the gap in the current literature by providing gait analysis for hemizygous M83+/- mice at 52 weeks of age, as these mice have a known pathological burden at this age and are expected to exhibit gait dysfunction. The gait analysis results at 52 weeks of age show an increase in the average limb stride length variability and average limb ataxia coefficient of M83+/- mice, indicating gait dysfunction. However, no significant differences in several other gait parameters, such as stride length and frequency, were observed at 52 weeks between the two groups. These results are consistent with human PD progression, in which pathological symptoms precede motor decline. These hemizygous mice show slow motor impairment and disease progression, thus making them suboptimal options for studying gait in PD. ( en )
General Note:
Awarded Bachelor of Science, magna cum laude, on May 6, 2023. Major: Nutritional Sciences
General Note:
College or School: Agricultural and Life Sciences
General Note:
Advisor: Vinata Vedam-Mai. Advisor Department or School: Neurology.

Record Information

Source Institution:
University of Florida
Holding Location:
University of Florida
Rights Management:
Copyright Xavier Becsey. Permission granted to the University of Florida to digitize, archive and distribute this item for non-profit research and educational purposes. Any reuse of this item in excess of fair use or other copyright exemptions requires permission of the copyright holder.

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mods:abstract lang en This study aimed to provide a deeper understanding of the motor impairments related to Parkinson's disease in the literature by analyzing the long-term gait performance of Parkinsonian mice possessing a unique a-syn misfolding and aggregation phenotype (M83+/-). The aim of this thesis was to conduct a comparative analysis of gait patterns between M83+/- mice and a control group at 12 and 52 weeks old. This research endeavor seeked to address the gap in the current literature by providing gait analysis for hemizygous M83+/- mice at 52 weeks of age, as these mice have a known pathological burden at this age and are expected to exhibit gait dysfunction. The gait analysis results at 52 weeks of age show an increase in the average limb stride length variability and average limb ataxia coefficient of M83+/- mice, indicating gait dysfunction. However, no significant differences in several other gait parameters, such as stride length and frequency, were observed at 52 weeks between the two groups. These results are consistent with human PD progression, in which pathological symptoms precede motor decline. These hemizygous mice show slow motor impairment and disease progression, thus making them suboptimal options for studying gait in PD.
mods:accessCondition Copyright Xavier Becsey. Permission granted to the University of Florida to digitize, archive and distribute this item for non-profit research and educational purposes. Any reuse of this item in excess of fair use or other copyright exemptions requires permission of the copyright holder.
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mods:languageTerm type text English
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mods:physicalLocation University of Florida
mods:name
mods:namePart Becsey, Xavier
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mods:note Awarded Bachelor of Science, magna cum laude, on April 29, 2022. Major: Nutritional Sciences
College or School: Agricultural and Life Sciences
Advisor: Vinata Vedam-Mai. Advisor Department or School: Neurology. Advisor: . Advisor Department or School:
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mods:publisher University of Florida
mods:dateIssued 2023
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mods:caption 2023
mods:subject
mods:topic Undergraduate Honors Thesis/Project
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mods:title Gait Analysis in Aged Parkinsonian Mice
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