|
Citation |
- Permanent Link:
- https://ufdc.ufl.edu/AA00054860/00037
Material Information
- Title:
- Multimodal Neuroimaging of the Basal Ganglia in Autism Spectrum Disorder and Relationships to Repetitive Behavior
- Series Title:
- 18th Annual Undergraduate Research Symposium
- Creator:
- Korah, Hannah
- Language:
- English
Subjects
- Subjects / Keywords:
- Center for Undergraduate Research
Psychology/Social Sciences
- Genre:
- Conference papers and proceedings
poster ( aat )
Notes
- Abstract:
- Restrictive repetitive behavior (RRB), such as insistence on sameness, self-injury, motor stereotypy, compulsions and rituals, are seemingly purposeless patterns of behavior that occur with high frequency and interfere with normal behaviors. RRB is diagnostic for autism spectrum disorder (ASD) and present in other neurodevelopmental disorders, including Rett syndrome, Fragile X syndrome, Obsessive-Compulsive Disorder and Prader-Willi syndrome. Neuroimaging studies have identified morphological alterations in the basal ganglia of individuals with ASD that are correlated with higher rates of RRB. In this study, we will assess morphology and structural connectivity in the basal ganglia of children with ASD and typically developing controls using magnetic resonance imaging (MRI) and diffusion tensor imaging (DTI) data acquired from the National Database for Autism Research. We will also assess how these neuroimaging measures relate to measures of RRB from the Autism Diagnostic Interview – Revised (ADI-R) among children with ASD. Novel findings from this study may increase understanding of the neural circuitry mediating RRB in ASD, and provide potential targets for biologically based treatments. Results from this study may also provide targets for more detailed mechanistic investigations in animal models of RRB. ( en )
- General Note:
- Research Authors: Hannah Korah, Carly Bass, Brad Wilkes, Marcelo Febo, Ph.D, Mark Lewis, Ph.D - University of Florida
- General Note:
- University Scholars Program
- General Note:
- Faculty Mentor: Mark Lewis - Psychology, University of Florida
Record Information
- Source Institution:
- University of Florida
- Rights Management:
- Copyright Hannah Korah. Permission granted to University of Florida to digitize and display this item for non-profit research and educational purposes. Any reuse of this item in excess of fair use or other copyright exemptions requires permission of the copyright holder.
|
Downloads |
This item is only available as the following downloads:
|
Full Text |
PAGE 1
! "#$%&'()*#!+#))*#!,#-.*'/&!0""123!$4(-!.$!'5$'$%#5(#!/5! $.6#5#$$3!$#789'5:4&;3!6/%/&!$%#/%;+;3!(/6+47$'/5$!.5#&5$!/8!,#-.*'/&!%-.%!/((4&!?'%-! -'=-!8@4#5(;!.5.5&:,7#-/+#( $,(>.+.::?.(4.-&?/,%@ V.55.-!Q/&.-3!W.&7;!1.$$3!1&.( >.#95$#( B9$9%.(E,%F( Y#&8/&6!'<#5)(.7!.5.7;$#$!/5!%-#!$.6#!'5<'*'<4.7$!%/!$#.&(-! 8/&!*/746#%&'(!<'I#(#$!%-.%!.%#!%/!+#))*#!,#-.*'/&!'5! /%-#&!='/5$3 !$4(-!.$!6/%/&!.5.3.%.7'.#( Ashburner J. & Friston K.J. (2000). Voxel-Based Morphometry--The Methods. NeuroImage 11(6): 805-21 Hollander E., Anagnostou E., Chaplin W., Esposito K., Haznedar M.M., Licalzi E., Wasserman S., Soorya L., & Buchsbaum M. (2005). Striatal Volume on Magnetic Resonance Imaging and Repetitive Behaviors in Autism. Biological Psychiatry 58(3): 226-232. Langen M., Dienke B., Noordermeer S.D., Nederveen H., van Engeland H. & Durston S. (2014). Changes in the Development of Striatum Are Involved in Repetitive Behavior in Autism. Biological Psychiatry 76(5): 405-11. Nelson A.B. & Kreitzer A.C. (2014). Reassessing Models of Basal Ganglia Function and Dysfunction. Annual Review of Neuroscience 37: 117-35. Rojas D.C., Peterson E., Winterrowd E., Reite M.L, Rogers S.J., & Tregellas J.R. (2006). Regional gray matter volumetric changes in autism associated with social and repetitive behavior symptoms. BMC Psychiatry, 6:56. DOI: 10.1186/1471-244X-6-56 Smith SM, Nichols TE. Threshold-free cluster enhancement: addressing problems of smoothing ]1H!$-/?$!%-.%!(-'7<!?'%-!BCD!#O-','%#
|
|